Principal Funds > Principal Exchange-Traded Funds
Principal Healthcare Innovators ETF
$42.95M
Avg Monthly Net Assets
$16.49M
Total Assets
$52K
Total Liabilities
$16.44M
Net Assets
Principal Healthcare Innovators ETF is an Exchange-Traded Fund in Principal Exchange-Traded Funds
from Principal Funds,
based in Iowa,
United States of America.
The fund has one share class
and monthly net assets of $42.95M.
On August 21st, 2024 it reported 268 holdings, the largest
being Alnylam Pharmaceuticals Inc (5.2%), Moderna Inc (3.6%) and Sarepta Therapeutics Inc (3.2%).
Data provided by Fincoded.
Share Classes
| Name | Class/Contract ID | Exchange | Ticker | Monthly Returns (2 years) |
|---|---|---|---|---|
| Principal Healthcare Innovators ETF | C000171494 | XNAS | BTEC |
Holdings
From latest NPORT-P, filed August 21st, 2024 for period ending June 30th, 2024.
Historic holdings data available from Fincoded.
| Name | Profile | Category | Country | Value $USD | # Shares | % of Fund |
|---|---|---|---|---|---|---|
| 10X Genomics, Inc. (10X Genomics Inc) | Long | Equity-common | US | $75K | 4K | 0.45 |
| 2seventy bio, Inc. (2seventy bio Inc) | Long | Equity-common | US | $10K | 3K | 0.06 |
| 4D Molecular Therapeutics, Inc. (4D Molecular Therapeutics Inc) | Long | Equity-common | US | $39K | 2K | 0.24 |
| 89bio, Inc. (89bio Inc) | Long | Equity-common | US | $29K | 4K | 0.17 |
| Accuray, Inc. (Accuray Inc) | Long | Equity-common | US | $10K | 5K | 0.06 |
| ACELYRIN, Inc. (ACELYRIN Inc) | Long | Equity-common | US | $18K | 4K | 0.11 |
| Aclaris Therapeutics, Inc. (Aclaris Therapeutics Inc) | Long | Equity-common | US | $7K | 6K | 0.04 |
| Actinium Pharmaceuticals, Inc. (Actinium Pharmaceuticals Inc) | Long | Equity-common | US | $11K | 2K | 0.07 |
| Adaptive Biotechnologies Corp. | Long | Equity-common | US | $23K | 6K | 0.14 |
| Adicet Bio, Inc. (Adicet Bio Inc) | Long | Equity-common | US | $6K | 5K | 0.04 |
| ADMA Biologics, Inc. (ADMA Biologics Inc) | Long | Equity-common | US | $98K | 9K | 0.60 |
| Aerovate Therapeutics, Inc. (Aerovate Therapeutics Inc) | Long | Equity-common | US | $2K | 1K | 0.01 |
| Agenus, Inc. (Agenus Inc) | Long | Equity-common | US | $19K | 1K | 0.11 |
| Agios Pharmaceuticals, Inc. (Agios Pharmaceuticals Inc) | Long | Equity-common | US | $93K | 2K | 0.56 |
| Akero Therapeutics, Inc. (Akero Therapeutics Inc) | Long | Equity-common | US | $60K | 3K | 0.36 |
| Akoya Biosciences, Inc. (Akoya Biosciences Inc) | Long | Equity-common | US | $6K | 3K | 0.04 |
| Aldeyra Therapeutics, Inc. (Aldeyra Therapeutics Inc) | Long | Equity-common | US | $11K | 3K | 0.07 |
| Alector, Inc. (Alector Inc) | Long | Equity-common | US | $18K | 4K | 0.11 |
| Allakos, Inc. (Allakos Inc) | Long | Equity-common | US | $7K | 7K | 0.04 |
| Allogene Therapeutics, Inc. (Allogene Therapeutics Inc) | Long | Equity-common | US | $16K | 7K | 0.10 |
| Alnylam Pharmaceuticals, Inc. (Alnylam Pharmaceuticals Inc) | Long | Equity-common | US | $855K | 4K | 5.20 |
| Alphatec Holdings, Inc. (Alphatec Holdings Inc) | Long | Equity-common | US | $53K | 5K | 0.32 |
| Altimmune, Inc. (Altimmune Inc) | Long | Equity-common | US | $15K | 2K | 0.09 |
| ALX Oncology Holdings, Inc. (ALX Oncology Holdings Inc) | Long | Equity-common | US | $13K | 2K | 0.08 |
| Amicus Therapeutics, Inc. (Amicus Therapeutics Inc) | Long | Equity-common | US | $106K | 11K | 0.65 |
| AnaptysBio, Inc. (AnaptysBio Inc) | Long | Equity-common | US | $28K | 1K | 0.17 |
| Anavex Life Sciences Corp. | Long | Equity-common | US | $16K | 4K | 0.10 |
| AngioDynamics, Inc. (AngioDynamics Inc) | Long | Equity-common | US | $13K | 2K | 0.08 |
| Anika Therapeutics, Inc. (Anika Therapeutics Inc) | Long | Equity-common | US | $17K | 687 | 0.11 |
| Annexon, Inc. (Annexon Inc) | Long | Equity-common | US | $16K | 3K | 0.10 |
| Apellis Pharmaceuticals, Inc. (Apellis Pharmaceuticals Inc) | Long | Equity-common | US | $164K | 4K | 1.00 |
| Apogee Therapeutics, Inc. (Apogee Therapeutics Inc) | Long | Equity-common | US | $64K | 2K | 0.39 |
| Arbutus Biopharma Corp. | Long | Equity-common | CA | $25K | 8K | 0.15 |
| Arcellx, Inc. (Arcellx Inc) | Long | Equity-common | US | $105K | 2K | 0.64 |
| Arcturus Therapeutics Holdings, Inc. (Arcturus Therapeutics Holdings Inc) | Long | Equity-common | US | $26K | 1K | 0.16 |
| Arcus Biosciences, Inc. (Arcus Biosciences Inc) | Long | Equity-common | US | $51K | 3K | 0.31 |
| Arcutis Biotherapeutics, Inc. (Arcutis Biotherapeutics Inc) | Long | Equity-common | US | $41K | 4K | 0.25 |
| Ardelyx, Inc. (Ardelyx Inc) | Long | Equity-common | US | $64K | 9K | 0.39 |
| ArriVent Biopharma, Inc. (ArriVent Biopharma Inc) | Long | Equity-common | US | $25K | 1K | 0.15 |
| Arrowhead Pharmaceuticals, Inc. (Arrowhead Pharmaceuticals Inc) | Long | Equity-common | US | $117K | 4K | 0.71 |
| ARS Pharmaceuticals, Inc. (ARS Pharmaceuticals Inc) | Long | Equity-common | US | $32K | 4K | 0.19 |
| Artivion, Inc. (Artivion Inc) | Long | Equity-common | US | $42K | 2K | 0.26 |
| Arvinas, Inc. (Arvinas Inc) | Long | Equity-common | US | $67K | 3K | 0.41 |
| Astria Therapeutics, Inc. (Astria Therapeutics Inc) | Long | Equity-common | US | $20K | 2K | 0.12 |
| Atara Biotherapeutics, Inc. (Atara Biotherapeutics Inc) | Long | Equity-common | US | $4K | 446 | 0.02 |
| Atea Pharmaceuticals, Inc. (Atea Pharmaceuticals Inc) | Long | Equity-common | US | $13K | 4K | 0.08 |
| AtriCure, Inc. (AtriCure Inc) | Long | Equity-common | US | $41K | 2K | 0.25 |
| Aura Biosciences, Inc. (Aura Biosciences Inc) | Long | Equity-common | US | $17K | 2K | 0.11 |
| Aurinia Pharmaceuticals, Inc. (Aurinia Pharmaceuticals Inc) | Long | Equity-common | CA | $34K | 6K | 0.20 |
| Avanos Medical, Inc. (Avanos Medical Inc) | Long | Equity-common | US | $36K | 2K | 0.22 |
| Avid Bioservices, Inc. (Avid Bioservices Inc) | Long | Equity-common | US | $20K | 3K | 0.12 |
| Avidity Biosciences, Inc. (Avidity Biosciences Inc) | Long | Equity-common | US | $123K | 3K | 0.75 |
| Avita Medical, Inc. (Avita Medical Inc) | Long | Equity-common | US | $9K | 1K | 0.06 |
| Axogen, Inc. (Axogen Inc) | Long | Equity-common | US | $15K | 2K | 0.09 |
| Axsome Therapeutics, Inc. (Axsome Therapeutics Inc) | Long | Equity-common | US | $138K | 2K | 0.84 |
| Azenta, Inc. (Azenta Inc) | Long | Equity-common | US | $107K | 2K | 0.65 |
| Beam Therapeutics, Inc. (Beam Therapeutics Inc) | Long | Equity-common | US | $71K | 3K | 0.43 |
| BioAtla, Inc. (BioAtla Inc) | Long | Equity-common | US | $4K | 3K | 0.03 |
| BioCryst Pharmaceuticals, Inc. (BioCryst Pharmaceuticals Inc) | Long | Equity-common | US | $49K | 8K | 0.30 |
| Biohaven Ltd. | Long | Equity-common | VG | $102K | 3K | 0.62 |
| BioLife Solutions, Inc. (BioLife Solutions Inc) | Long | Equity-common | US | $39K | 2K | 0.23 |
| Biomea Fusion, Inc. (Biomea Fusion Inc) | Long | Equity-common | US | $7K | 2K | 0.04 |
| Bioxcel Therapeutics, Inc. (Bioxcel Therapeutics Inc) | Long | Equity-common | US | $4K | 3K | 0.02 |
| Bluebird Bio, Inc. (Bluebird Bio Inc) | Long | Equity-common | US | $10K | 10K | 0.06 |
| Blueprint Medicines Corp. | Long | Equity-common | US | $237K | 2K | 1.44 |
| Bridgebio Pharma, Inc. (Bridgebio Pharma Inc) | Long | Equity-common | US | $166K | 7K | 1.01 |
| Butterfly Network, Inc. (Butterfly Network Inc) | Long | Equity-common | US | $9K | 10K | 0.05 |
| Cabaletta Bio, Inc. (Cabaletta Bio Inc) | Long | Equity-common | US | $14K | 2K | 0.09 |
| CareDx, Inc. (CareDx Inc) | Long | Equity-common | US | $34K | 2K | 0.21 |
| Cargo Therapeutics, Inc. (Cargo Therapeutics Inc) | Long | Equity-common | US | $26K | 2K | 0.16 |
| Caribou Biosciences, Inc. (Caribou Biosciences Inc) | Long | Equity-common | US | $7K | 4K | 0.04 |
| Cassava Sciences, Inc. (Cassava Sciences Inc) | Long | Equity-common | US | $21K | 2K | 0.13 |
| Catalent, Inc. (Catalent Inc) | Long | Equity-common | US | $361K | 6K | 2.19 |
| Celcuity, Inc. (Celcuity Inc) | Long | Equity-common | US | $17K | 1K | 0.10 |
| Celldex Therapeutics, Inc. (Celldex Therapeutics Inc) | Long | Equity-common | US | $89K | 2K | 0.54 |
| Cerevel Therapeutics Holdings, Inc. (Cerevel Therapeutics Holdings Inc) | Long | Equity-common | US | $263K | 6K | 1.60 |
| Cerus Corp. | Long | Equity-common | US | $15K | 9K | 0.09 |
| CG oncology, Inc. (CG oncology Inc) | Long | Equity-common | US | $78K | 2K | 0.47 |
| Chinook Therapeutics, Inc. (CONTRA CHINOOK THERAPE) | Long | Equity-common | US | $4K | 9K | 0.02 |
| ClearPoint Neuro, Inc. (ClearPoint Neuro Inc) | Long | Equity-common | US | $9K | 2K | 0.05 |
| Codexis, Inc. (Codexis Inc) | Long | Equity-common | US | $12K | 4K | 0.07 |
| Cogent Biosciences, Inc. (Cogent Biosciences Inc) | Long | Equity-common | US | $36K | 4K | 0.22 |
| Coherus Biosciences, Inc. (Coherus Biosciences Inc) | Long | Equity-common | US | $10K | 6K | 0.06 |
| CorMedix, Inc. (CorMedix Inc) | Long | Equity-common | US | $13K | 3K | 0.08 |
| Crinetics Pharmaceuticals, Inc. (Crinetics Pharmaceuticals Inc) | Long | Equity-common | US | $126K | 3K | 0.77 |
| CryoPort, Inc. (CryoPort Inc) | Long | Equity-common | US | $13K | 2K | 0.08 |
| Cullinan Therapeutics, Inc. (Cullinan Therapeutics Inc) | Long | Equity-common | US | $30K | 2K | 0.18 |
| Cutera, Inc. (Cutera Inc) | Long | Equity-common | US | $6K | 4K | 0.04 |
| CVRx, Inc. (CVRx Inc) | Long | Equity-common | US | $12K | 978 | 0.07 |
| Cytek Biosciences, Inc. (Cytek Biosciences Inc) | Long | Equity-common | US | $29K | 5K | 0.18 |
| Cytokinetics, Inc. (Cytokinetics Inc) | Long | Equity-common | US | $198K | 4K | 1.20 |
| Day One Biopharmaceuticals, Inc. (Day One Biopharmaceuticals Inc) | Long | Equity-common | US | $45K | 3K | 0.27 |
| Denali Therapeutics, Inc. (Denali Therapeutics Inc) | Long | Equity-common | US | $118K | 5K | 0.72 |
| Disc Medicine, Inc. (Disc Medicine Inc) | Long | Equity-common | US | $41K | 912 | 0.25 |
| Dyne Therapeutics, Inc. (Dyne Therapeutics Inc) | Long | Equity-common | US | $106K | 3K | 0.64 |
| Edgewise Therapeutics, Inc. (Edgewise Therapeutics Inc) | Long | Equity-common | US | $62K | 3K | 0.38 |
| Editas Medicine, Inc. (Editas Medicine Inc) | Long | Equity-common | US | $16K | 3K | 0.10 |
| Elanco Animal Health, Inc. (Elanco Animal Health Inc) | Long | Equity-common | US | $253K | 18K | 1.54 |
| Emergent BioSolutions, Inc. (Emergent BioSolutions Inc) | Long | Equity-common | US | $25K | 4K | 0.15 |
| Enanta Pharmaceuticals, Inc. (Enanta Pharmaceuticals Inc) | Long | Equity-common | US | $13K | 994 | 0.08 |
| Enliven Therapeutics, Inc. (Enliven Therapeutics Inc) | Long | Equity-common | US | $39K | 2K | 0.24 |
| Enovis Corp. | Long | Equity-common | US | $90K | 2K | 0.55 |
| Entrada Therapeutics, Inc. (Entrada Therapeutics Inc) | Long | Equity-common | US | $21K | 1K | 0.13 |
| Erasca, Inc. (Erasca Inc) | Long | Equity-common | US | $18K | 7K | 0.11 |
| Evolus, Inc. (Evolus Inc) | Long | Equity-common | US | $26K | 2K | 0.16 |
| Exact Sciences Corp. | Long | Equity-common | US | $272K | 6K | 1.65 |
| Eyenovia, Inc. (Eyenovia Inc) | Long | Equity-common | US | $4K | 6K | 0.02 |
| EyePoint Pharmaceuticals, Inc. (EyePoint Pharmaceuticals Inc) | Long | Equity-common | US | $17K | 2K | 0.10 |
| Fate Therapeutics, Inc. (Fate Therapeutics Inc) | Long | Equity-common | US | $13K | 4K | 0.08 |
| Fennec Pharmaceuticals, Inc. (Fennec Pharmaceuticals Inc) | Long | Equity-common | CA | $8K | 1K | 0.05 |
| FibroGen, Inc. (FibroGen Inc) | Long | Equity-common | US | $5K | 5K | 0.03 |
| Genelux Corp. | Long | Equity-common | US | $3K | 2K | 0.02 |
| Geron Corp. | Long | Equity-common | US | $88K | 21K | 0.54 |
| Glaukos Corp. | Long | Equity-common | US | $209K | 2K | 1.27 |
| GRAIL, Inc. (GRAIL Inc) | Long | Equity-common | US | $10K | 641 | 0.06 |
| Gritstone bio, Inc. (Gritstone bio Inc) | Long | Equity-common | US | $3K | 5K | 0.02 |
| Harrow, Inc. (Harrow Inc) | Long | Equity-common | US | $33K | 2K | 0.20 |
| Heron Therapeutics, Inc. (Heron Therapeutics Inc) | Long | Equity-common | US | $24K | 7K | 0.15 |
| HilleVax, Inc. (HilleVax Inc) | Long | Equity-common | US | $29K | 2K | 0.17 |
| Humacyte, Inc. (Humacyte Inc) | Long | Equity-common | US | $27K | 6K | 0.16 |
| ICU Medical, Inc. (ICU Medical Inc) | Long | Equity-common | US | $106K | 889 | 0.64 |
| Ideaya Biosciences, Inc. (Ideaya Biosciences Inc) | Long | Equity-common | US | $95K | 3K | 0.58 |
| IGM Biosciences, Inc. (IGM Biosciences Inc) | Long | Equity-common | US | $11K | 2K | 0.07 |
| Illumina, Inc. (Illumina Inc) | Long | Equity-common | US | $401K | 4K | 2.44 |
| ImmunityBio, Inc. (ImmunityBio Inc) | Long | Equity-common | US | $154K | 24K | 0.94 |
| Immunovant, Inc. (Immunovant Inc) | Long | Equity-common | US | $137K | 5K | 0.84 |
| Inari Medical, Inc. (Inari Medical Inc) | Long | Equity-common | US | $103K | 2K | 0.63 |
| Inogen, Inc. (Inogen Inc) | Long | Equity-common | US | $11K | 1K | 0.07 |
| Inozyme Pharma, Inc. (Inozyme Pharma Inc) | Long | Equity-common | US | $12K | 3K | 0.07 |
| Insmed, Inc. (Insmed Inc) | Long | Equity-common | US | $358K | 5K | 2.18 |
| Inspire Medical Systems, Inc. (Inspire Medical Systems Inc) | Long | Equity-common | US | $142K | 1K | 0.87 |
| Intellia Therapeutics, Inc. (Intellia Therapeutics Inc) | Long | Equity-common | US | $80K | 4K | 0.49 |
| Intra-Cellular Therapies, Inc. (Intra-Cellular Therapies Inc) | Long | Equity-common | US | $235K | 3K | 1.43 |
| Ionis Pharmaceuticals, Inc. (Ionis Pharmaceuticals Inc) | Long | Equity-common | US | $247K | 5K | 1.50 |
| Iovance Biotherapeutics, Inc. (Iovance Biotherapeutics Inc) | Long | Equity-common | US | $81K | 10K | 0.49 |
| iRhythm Technologies, Inc. (iRhythm Technologies Inc) | Long | Equity-common | US | $120K | 1K | 0.73 |
| iTeos Therapeutics, Inc. (iTeos Therapeutics Inc) | Long | Equity-common | US | $23K | 2K | 0.14 |
| Janux Therapeutics, Inc. (Janux Therapeutics Inc) | Long | Equity-common | US | $82K | 2K | 0.50 |
| KalVista Pharmaceuticals, Inc. (KalVista Pharmaceuticals Inc) | Long | Equity-common | US | $22K | 2K | 0.13 |
| Karyopharm Therapeutics, Inc. (Karyopharm Therapeutics Inc) | Long | Equity-common | US | $6K | 7K | 0.04 |
| Keros Therapeutics, Inc. (Keros Therapeutics Inc) | Long | Equity-common | US | $61K | 1K | 0.37 |
| Kiniksa Pharmaceuticals International PLC | Long | Equity-common | GB | $30K | 2K | 0.18 |
| Kodiak Sciences, Inc. (Kodiak Sciences Inc) | Long | Equity-common | US | $6K | 3K | 0.04 |
| Kura Oncology, Inc. (Kura Oncology Inc) | Long | Equity-common | US | $58K | 3K | 0.35 |
| Kymera Therapeutics, Inc. (Kymera Therapeutics Inc) | Long | Equity-common | US | $68K | 2K | 0.41 |
| Larimar Therapeutics, Inc. (Larimar Therapeutics Inc) | Long | Equity-common | US | $20K | 3K | 0.12 |
| Lexeo Therapeutics, Inc. (Lexeo Therapeutics Inc) | Long | Equity-common | US | $19K | 1K | 0.12 |
| Lexicon Pharmaceuticals, Inc. (Lexicon Pharmaceuticals Inc) | Long | Equity-common | US | $17K | 10K | 0.11 |
| Liquidia Corp. | Long | Equity-common | US | $35K | 3K | 0.21 |
| Longboard Pharmaceuticals, Inc. (Longboard Pharmaceuticals Inc) | Long | Equity-common | US | $37K | 1K | 0.22 |
| Lyell Immunopharma, Inc. (Lyell Immunopharma Inc) | Long | Equity-common | US | $16K | 11K | 0.10 |
| MacroGenics, Inc. (MacroGenics Inc) | Long | Equity-common | US | $10K | 2K | 0.06 |
| Madrigal Pharmaceuticals, Inc. (Madrigal Pharmaceuticals Inc) | Long | Equity-common | US | $201K | 718 | 1.22 |
| Maravai LifeSciences Holdings, Inc. (Maravai LifeSciences Holdings Inc) | Long | Equity-common | US | $36K | 5K | 0.22 |
| Marinus Pharmaceuticals, Inc. (Marinus Pharmaceuticals Inc) | Long | Equity-common | US | $3K | 2K | 0.02 |
| MaxCyte, Inc. (MaxCyte Inc) | Long | Equity-common | US | $18K | 5K | 0.11 |
| MeiraGTx Holdings PLC | Long | Equity-common | KY | $12K | 3K | 0.08 |
| Mersana Therapeutics, Inc. (Mersana Therapeutics Inc) | Long | Equity-common | US | $10K | 5K | 0.06 |
| Mineralys Therapeutics, Inc. (Mineralys Therapeutics Inc) | Long | Equity-common | US | $24K | 2K | 0.15 |
| Mirum Pharmaceuticals, Inc. (Mirum Pharmaceuticals Inc) | Long | Equity-common | US | $61K | 2K | 0.37 |
| Moderna, Inc. (Moderna Inc) | Long | Equity-common | US | $588K | 5K | 3.58 |
| Morphic Holding, Inc. (Morphic Holding Inc) | Long | Equity-common | US | $65K | 2K | 0.40 |
| Mural Oncology PLC | Long | Equity-common | IE | $5K | 2K | 0.03 |
| Myriad Genetics, Inc. (Myriad Genetics Inc) | Long | Equity-common | US | $83K | 3K | 0.51 |
| Natera, Inc. (Natera Inc) | Long | Equity-common | US | $464K | 4K | 2.82 |
| Neumora Therapeutics, Inc. (Neumora Therapeutics Inc) | Long | Equity-common | US | $57K | 6K | 0.35 |
| Nevro Corp. | Long | Equity-common | US | $13K | 2K | 0.08 |
| Nkarta, Inc. (Nkarta Inc) | Long | Equity-common | US | $17K | 3K | 0.10 |
| Novavax, Inc. (Novavax Inc) | Long | Equity-common | US | $75K | 6K | 0.46 |
| Novocure Ltd. | Long | Equity-common | JE | $70K | 4K | 0.43 |
| Nurix Therapeutics, Inc. (Nurix Therapeutics Inc) | Long | Equity-common | US | $42K | 2K | 0.25 |
| Nuvalent, Inc. (Nuvalent Inc) | Long | Equity-common | US | $160K | 2K | 0.97 |
| Nuvation Bio, Inc. (Nuvation Bio Inc) | Long | Equity-common | US | $26K | 9K | 0.16 |
| Ocular Therapeutix, Inc. (Ocular Therapeutix Inc) | Long | Equity-common | US | $38K | 6K | 0.23 |
| Olema Pharmaceuticals, Inc. (Olema Pharmaceuticals Inc) | Long | Equity-common | US | $25K | 2K | 0.15 |
| Omega Therapeutics, Inc. (Omega Therapeutics Inc) | Long | Equity-common | US | $7K | 3K | 0.04 |
| Omeros Corp. | Long | Equity-common | US | $14K | 4K | 0.09 |
| OmniAb, Inc. (OmniAb Inc) | Long | Equity-common | US | $18K | 5K | 0.11 |
| OmniAb, Inc. (OMNIAB INC) | Long | Equity-common | US | $0 | 977 | – |
| OmniAb, Inc. (OMNIAB INC) | Long | Equity-common | US | $0 | 977 | – |
| ORIC Pharmaceuticals, Inc. (ORIC Pharmaceuticals Inc) | Long | Equity-common | US | $19K | 3K | 0.11 |
| Orthofix Medical, Inc. (Orthofix Medical Inc) | Long | Equity-common | US | $21K | 2K | 0.13 |
| OrthoPediatrics Corp. | Long | Equity-common | US | $28K | 963 | 0.17 |
| Outset Medical, Inc. (Outset Medical Inc) | Long | Equity-common | US | $15K | 4K | 0.09 |
| Pacific Biosciences of California, Inc. (Pacific Biosciences of California Inc) | Long | Equity-common | US | $14K | 10K | 0.09 |
| Paragon 28, Inc. (Paragon 28 Inc) | Long | Equity-common | US | $22K | 3K | 0.13 |
| PDS Biotechnology Corp. | Long | Equity-common | US | $7K | 2K | 0.04 |
| PepGen, Inc. (PepGen Inc) | Long | Equity-common | US | $23K | 1K | 0.14 |
| Phathom Pharmaceuticals, Inc. (Phathom Pharmaceuticals Inc) | Long | Equity-common | US | $25K | 2K | 0.15 |
| Pliant Therapeutics, Inc. (Pliant Therapeutics Inc) | Long | Equity-common | US | $26K | 2K | 0.16 |
| PMV Pharmaceuticals, Inc. (PMV Pharmaceuticals Inc) | Long | Equity-common | US | $7K | 5K | 0.04 |
| Poseida Therapeutics, Inc. (Poseida Therapeutics Inc) | Long | Equity-common | US | $14K | 5K | 0.08 |
| Precigen, Inc. (Precigen Inc) | Long | Equity-common | US | $19K | 12K | 0.11 |
| Prime Medicine, Inc. (Prime Medicine Inc) | Long | Equity-common | US | $24K | 5K | 0.15 |
| Principal Government Money Market Fund | Long | Short-term investment vehicle | US | $44K | 44K | 0.27 |
| PROCEPT BioRobotics Corp. | Long | Equity-common | US | $115K | 2K | 0.70 |
| Protagonist Therapeutics, Inc. (Protagonist Therapeutics Inc) | Long | Equity-common | US | $77K | 2K | 0.47 |
| Prothena Corp. PLC (Prothena Corp PLC) | Long | Equity-common | IE | $42K | 2K | 0.25 |
| PTC Therapeutics, Inc. (PTC Therapeutics Inc) | Long | Equity-common | US | $87K | 3K | 0.53 |
| Pulmonx Corp. | Long | Equity-common | US | $12K | 2K | 0.07 |
| Pulse Biosciences, Inc. (Pulse Biosciences Inc) | Long | Equity-common | US | $27K | 2K | 0.16 |
| Quanterix Corp. | Long | Equity-common | US | $20K | 1K | 0.12 |
| Quantum-Si, Inc. (Quantum-Si Inc) | Long | Equity-common | US | $7K | 7K | 0.04 |
| RAPT Therapeutics, Inc. (RAPT Therapeutics Inc) | Long | Equity-common | US | $5K | 2K | 0.03 |
| Recursion Pharmaceuticals, Inc. (Recursion Pharmaceuticals Inc) | Long | Equity-common | US | $59K | 8K | 0.36 |
| REGENXBIO, Inc. (REGENXBIO Inc) | Long | Equity-common | US | $22K | 2K | 0.14 |
| Relay Therapeutics, Inc. (Relay Therapeutics Inc) | Long | Equity-common | US | $33K | 5K | 0.20 |
| Replimune Group, Inc. (Replimune Group Inc) | Long | Equity-common | US | $24K | 3K | 0.15 |
| Revance Therapeutics, Inc. (Revance Therapeutics Inc) | Long | Equity-common | US | $12K | 5K | 0.07 |
| REVOLUTION Medicines, Inc. (REVOLUTION Medicines Inc) | Long | Equity-common | US | $228K | 6K | 1.38 |
| Rhythm Pharmaceuticals, Inc. (Rhythm Pharmaceuticals Inc) | Long | Equity-common | US | $92K | 2K | 0.56 |
| Rigel Pharmaceuticals, Inc. (Rigel Pharmaceuticals Inc) | Long | Equity-common | US | $8K | 916.8 | 0.05 |
| Rocket Pharmaceuticals, Inc. (Rocket Pharmaceuticals Inc) | Long | Equity-common | US | $73K | 3K | 0.44 |
| Roivant Sciences Ltd. | Long | Equity-common | BM | $303K | 29K | 1.84 |
| RxSight, Inc. (RxSight Inc) | Long | Equity-common | US | $85K | 1K | 0.51 |
| Sage Therapeutics, Inc. (Sage Therapeutics Inc) | Long | Equity-common | US | $25K | 2K | 0.15 |
| Sagimet Biosciences, Inc. (Sagimet Biosciences Inc) | Long | Equity-common | US | $6K | 2K | 0.03 |
| Sana Biotechnology, Inc. (Sana Biotechnology Inc) | Long | Equity-common | US | $45K | 8K | 0.28 |
| Sangamo Therapeutics, Inc. (Sangamo Therapeutics Inc) | Long | Equity-common | US | $5K | 14K | 0.03 |
| Sarepta Therapeutics, Inc. (Sarepta Therapeutics Inc) | Long | Equity-common | US | $525K | 3K | 3.19 |
| Savara, Inc. (Savara Inc) | Long | Equity-common | US | $23K | 6K | 0.14 |
| Scholar Rock Holding Corp. | Long | Equity-common | US | $24K | 3K | 0.15 |
| Scilex Holding Co. | Long | Equity-common | US | $19K | 10K | 0.12 |
| scPharmaceuticals, Inc. (scPharmaceuticals Inc) | Long | Equity-common | US | $9K | 2K | 0.06 |
| Seres Therapeutics, Inc. (Seres Therapeutics Inc) | Long | Equity-common | US | $8K | 11K | 0.05 |
| SI-BONE, Inc. (SI-BONE Inc) | Long | Equity-common | US | $22K | 2K | 0.13 |
| SIGA Technologies, Inc. (SIGA Technologies Inc) | Long | Equity-common | US | $23K | 3K | 0.14 |
| Silk Road Medical, Inc. (Silk Road Medical Inc) | Long | Equity-common | US | $43K | 2K | 0.26 |
| SpringWorks Therapeutics, Inc. (SpringWorks Therapeutics Inc) | Long | Equity-common | US | $100K | 3K | 0.61 |
| State Street Institutional U.S. Government Money Market Fund Premier Class (State Street Institutional US Government Money Market Fund) | Long | Short-term investment vehicle | US | $49K | 49K | 0.30 |
| Summit Therapeutics, Inc. (Summit Therapeutics Inc) | Long | Equity-common | US | $200K | 26K | 1.22 |
| Surmodics, Inc. (Surmodics Inc) | Long | Equity-common | US | $27K | 642 | 0.16 |
| Sutro Biopharma, Inc. (Sutro Biopharma Inc) | Long | Equity-common | US | $9K | 3K | 0.05 |
| Syndax Pharmaceuticals, Inc. (Syndax Pharmaceuticals Inc) | Long | Equity-common | US | $66K | 3K | 0.40 |
| Tandem Diabetes Care, Inc. (Tandem Diabetes Care Inc) | Long | Equity-common | US | $97K | 2K | 0.59 |
| Tango Therapeutics, Inc. (Tango Therapeutics Inc) | Long | Equity-common | US | $36K | 4K | 0.22 |
| Tarsus Pharmaceuticals, Inc. (Tarsus Pharmaceuticals Inc) | Long | Equity-common | US | $38K | 1K | 0.23 |
| Tenaya Therapeutics, Inc. (Tenaya Therapeutics Inc) | Long | Equity-common | US | $11K | 4K | 0.07 |
| Terns Pharmaceuticals, Inc. (Terns Pharmaceuticals Inc) | Long | Equity-common | US | $20K | 3K | 0.12 |
| TG Therapeutics, Inc. (TG Therapeutics Inc) | Long | Equity-common | US | $101K | 6K | 0.62 |
| Theravance Biopharma, Inc. (Theravance Biopharma Inc) | Long | Equity-common | KY | $18K | 2K | 0.11 |
| Third Harmonic Bio, Inc. (Third Harmonic Bio Inc) | Long | Equity-common | US | $24K | 2K | 0.15 |
| TransMedics Group, Inc. (TransMedics Group Inc) | Long | Equity-common | US | $181K | 1K | 1.10 |
| Travere Therapeutics, Inc. (Travere Therapeutics Inc) | Long | Equity-common | US | $26K | 3K | 0.16 |
| Treace Medical Concepts, Inc. (Treace Medical Concepts Inc) | Long | Equity-common | US | $16K | 2K | 0.10 |
| Twist Bioscience Corp. | Long | Equity-common | US | $106K | 2K | 0.65 |
| Tyra Biosciences, Inc. (Tyra Biosciences Inc) | Long | Equity-common | US | $33K | 2K | 0.20 |
| Ultragenyx Pharmaceutical, Inc. (Ultragenyx Pharmaceutical Inc) | Long | Equity-common | US | $122K | 3K | 0.74 |
| UroGen Pharma Ltd. | Long | Equity-common | IL | $25K | 1K | 0.15 |
| Vaxcyte, Inc. (Vaxcyte Inc) | Long | Equity-common | US | $290K | 4K | 1.76 |
| Ventyx Biosciences, Inc. (Ventyx Biosciences Inc) | Long | Equity-common | US | $7K | 3K | 0.04 |
| Vera Therapeutics, Inc. (Vera Therapeutics Inc) | Long | Equity-common | US | $74K | 2K | 0.45 |
| Veracyte, Inc. (Veracyte Inc) | Long | Equity-common | US | $60K | 3K | 0.37 |
| Vericel Corp. | Long | Equity-common | US | $82K | 2K | 0.50 |
| Verve Therapeutics, Inc. (Verve Therapeutics Inc) | Long | Equity-common | US | $15K | 3K | 0.09 |
| Viking Therapeutics, Inc. (Viking Therapeutics Inc) | Long | Equity-common | US | $205K | 4K | 1.24 |
| Vir Biotechnology, Inc. (Vir Biotechnology Inc) | Long | Equity-common | US | $45K | 5K | 0.27 |
| Viridian Therapeutics, Inc. (Viridian Therapeutics Inc) | Long | Equity-common | US | $31K | 2K | 0.19 |
| Voyager Therapeutics, Inc. (Voyager Therapeutics Inc) | Long | Equity-common | US | $19K | 2K | 0.11 |
| WaVe Life Sciences Ltd. | Long | Equity-common | SG | $25K | 5K | 0.15 |
| X4 Pharmaceuticals, Inc. (X4 Pharmaceuticals Inc) | Long | Equity-common | US | $5K | 9K | 0.03 |
| Xencor, Inc. (Xencor Inc) | Long | Equity-common | US | $44K | 2K | 0.27 |
| Xeris Biopharma Holdings, Inc. (Xeris Biopharma Holdings Inc) | Long | Equity-common | US | $16K | 7K | 0.09 |
| Y-mAbs Therapeutics, Inc. (Y-mAbs Therapeutics Inc) | Long | Equity-common | US | $22K | 2K | 0.13 |
| Zentalis Pharmaceuticals, Inc. (Zentalis Pharmaceuticals Inc) | Long | Equity-common | US | $11K | 3K | 0.07 |
| Zevra Therapeutics, Inc. (Zevra Therapeutics Inc) | Long | Equity-common | US | $11K | 2K | 0.07 |
| Zimvie, Inc. (Zimvie Inc) | Long | Equity-common | US | $22K | 1K | 0.13 |
| Zymeworks, Inc. (Zymeworks Inc) | Long | Equity-common | US | $24K | 3K | 0.15 |
Address
Principal Exchange-Traded Funds
801 Grand Avenue
DES MOINES
Iowa
50309
United States of America
Websites
Directors
Thomas A. Swank
Craig Damos
Katharin S. Dyer
Ken McCullum
Kamal Bhatia
Karen McMillan
Elizabeth A. Nickels
Victor Hymes
Frances P. Grieb
Padelford L. Lattimer
Transfer Agents
State Street Bank and Trust Company
Pricing Services
London Stock Exchange Group PLC
S&P Global Inc.
PricingDirect Inc.
ICE Data Pricing & Reference Data, LLC
Bloomberg L.P.
Chicago Mercantile Exchange Inc.
Custodians
Euroclear Bank
State Street Bank and Trust Company
Shareholder Servicing Agents
State Street Bank and Trust Company
Admins
State Street Bank and Trust Company
Principal Global Investors, LLC
Brokers
Barclays Capital Inc.